Comments on: Bodyweight Regulation: Leptin Part 2 http://www.bodyrecomposition.com/fat-loss/the-hormones-of-bodyweight-regulation-leptin-part-2.html Training and Nutrition advice, straight from the monkey's mouth. Sun, 22 Jan 2012 21:56:52 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: Tim Berzins http://www.bodyrecomposition.com/fat-loss/the-hormones-of-bodyweight-regulation-leptin-part-2.html/comment-page-1#comment-3127 Tim Berzins Thu, 20 Aug 2009 01:07:04 +0000 http://www.bodyrecomposition.com/blog/2008/08/15/the-hormones-of-bodyweight-regulation-leptin-part-2/#comment-3127 "Women’s brains appear to respond more to changes in leptin while men’s respond more to insulin. As you’d expect, these effects are probably mediated by differences in hormone levels and it appears that estrogen improves the sensitivity of the brain to leptin. While not tested in humans, estrogen injected into male rats increases the response to leptin." This is extremely interesting since insulin causes less testosterone to bind to SHBG. Since men's brain's respond more to insulin it seems as if testosterone and estrogen (obviously the hormones that have the greatest difference in males and females) may be related to weight loss in males in females via insulin and leptin repectively. All in all, really interesting shit. “Women’s brains appear to respond more to changes in leptin while men’s respond more to insulin. As you’d expect, these effects are probably mediated by differences in hormone levels and it appears that estrogen improves the sensitivity of the brain to leptin. While not tested in humans, estrogen injected into male rats increases the response to leptin.”

This is extremely interesting since insulin causes less testosterone to bind to SHBG. Since men’s brain’s respond more to insulin it seems as if testosterone and estrogen (obviously the hormones that have the greatest difference in males and females) may be related to weight loss in males in females via insulin and leptin repectively.

All in all, really interesting shit.

]]> By: Quasi-rhetorical questions re: carbs, leptin, and other « What’s Cooking in Suburbia http://www.bodyrecomposition.com/fat-loss/the-hormones-of-bodyweight-regulation-leptin-part-2.html/comment-page-1#comment-1423 Quasi-rhetorical questions re: carbs, leptin, and other « What’s Cooking in Suburbia Sun, 25 Jan 2009 03:38:43 +0000 http://www.bodyrecomposition.com/blog/2008/08/15/the-hormones-of-bodyweight-regulation-leptin-part-2/#comment-1423 [...] it sends a signal to the brain as to the body’s state of energy availability. (According to McDonald, Leptin scales with 1. body fat percentage, and 2. carbohydrate metabolism within fat cells. [...] [...] it sends a signal to the brain as to the body’s state of energy availability. (According to McDonald, Leptin scales with 1. body fat percentage, and 2. carbohydrate metabolism within fat cells. [...]

]]> By: Gestational Diabetes http://www.bodyrecomposition.com/fat-loss/the-hormones-of-bodyweight-regulation-leptin-part-2.html/comment-page-1#comment-134 Gestational Diabetes Sat, 13 Sep 2008 13:53:58 +0000 http://www.bodyrecomposition.com/blog/2008/08/15/the-hormones-of-bodyweight-regulation-leptin-part-2/#comment-134 [...] Comment on The hormones of bodyweight regulation: Leptin Part 2 by … [...] [...] Comment on The hormones of bodyweight regulation: Leptin Part 2 by … [...]

]]> By: It Ain’t Leptin, Either « Lots LessLiz http://www.bodyrecomposition.com/fat-loss/the-hormones-of-bodyweight-regulation-leptin-part-2.html/comment-page-1#comment-133 It Ain’t Leptin, Either « Lots LessLiz Tue, 09 Sep 2008 22:56:56 +0000 http://www.bodyrecomposition.com/blog/2008/08/15/the-hormones-of-bodyweight-regulation-leptin-part-2/#comment-133 [...] Part 2 [...] [...] Part 2 [...]

]]> By: itsthewooo http://www.bodyrecomposition.com/fat-loss/the-hormones-of-bodyweight-regulation-leptin-part-2.html/comment-page-1#comment-132 itsthewooo Thu, 04 Sep 2008 23:05:14 +0000 http://www.bodyrecomposition.com/blog/2008/08/15/the-hormones-of-bodyweight-regulation-leptin-part-2/#comment-132 I'm a female who has lost 160 lbs. I maintain a weight of 120 (within ~5 lb) and have for a few years (BMI ~20). I had long suspected I was severely leptin deficient as a result of weight loss. I confirmed my suspicions 7 months ago, when I agreed to participate in a study which replaces leptin in women who have leptin deficiency (because of my leptin deficiency I had been amenorrhetic for 4 years, and the study is about amenorrhea). Since replacing the leptin I feel so much better (mood, hunger, too many to list), and have resumed regular menstrual cycles. I feel like a normal weight person, before I felt starving (even when not acutely hungry, I always felt like a "starving person" ). I have long suspected women find it more difficult than men to lose weight primarily because leptin is a female hormone. Leptin is important in both genders, of course, but I think it affects women *way* more than men. A lot of women seem to be able to relate to my struggles after weight loss (mood, hunger, fertility). Men seem to respond to weight loss as if not much changed. I also definitely agree estrogen has "leptin like" effects; I've observed that I feel the most "leptin-like" when estrogen is highest (e.g. before ovulation). Doing research I discovered estrogen actually makes leptin, and estrogen controls how sensitive the brain is to leptin (injecting mice brains with leptin does very little if they are estrogen deficient; estrogen controls CNS response to leptin). Since leptin itself is necessary for adequate estrogen, we can see a feedback and direct relationship of leptin and estrogen. I disagree refeeds do much to really ameliorate leptin deficiency. Prior to leptin replacement, I did notice a day after a buffet pig out I felt "normal" and very good... but it only lasted a day, \which is far too little to counterbalance the amount of calories it took to create that feeling. I suspect that the leptin increase to overfeeding is proportional to the calorie excess created, and once a calorie deficit is recreated (either due to the satiety of the leptin or purposeful restriction) then the leptin will plummet again. This is my experience with refeeds, anyway. I’m a female who has lost 160 lbs. I maintain a weight of 120 (within ~5 lb) and have for a few years (BMI ~20). I had long suspected I was severely leptin deficient as a result of weight loss. I confirmed my suspicions 7 months ago, when I agreed to participate in a study which replaces leptin in women who have leptin deficiency (because of my leptin deficiency I had been amenorrhetic for 4 years, and the study is about amenorrhea).

Since replacing the leptin I feel so much better (mood, hunger, too many to list), and have resumed regular menstrual cycles. I feel like a normal weight person, before I felt starving (even when not acutely hungry, I always felt like a “starving person” ).

I have long suspected women find it more difficult than men to lose weight primarily because leptin is a female hormone. Leptin is important in both genders, of course, but I think it affects women *way* more than men. A lot of women seem to be able to relate to my struggles after weight loss (mood, hunger, fertility). Men seem to respond to weight loss as if not much changed.

I also definitely agree estrogen has “leptin like” effects; I’ve observed that I feel the most “leptin-like” when estrogen is highest (e.g. before ovulation). Doing research I discovered estrogen actually makes leptin, and estrogen controls how sensitive the brain is to leptin (injecting mice brains with leptin does very little if they are estrogen deficient; estrogen controls CNS response to leptin). Since leptin itself is necessary for adequate estrogen, we can see a feedback and direct relationship of leptin and estrogen.

I disagree refeeds do much to really ameliorate leptin deficiency. Prior to leptin replacement, I did notice a day after a buffet pig out I felt “normal” and very good… but it only lasted a day, \which is far too little to counterbalance the amount of calories it took to create that feeling. I suspect that the leptin increase to overfeeding is proportional to the calorie excess created, and once a calorie deficit is recreated (either due to the satiety of the leptin or purposeful restriction) then the leptin will plummet again. This is my experience with refeeds, anyway.

]]> By: Warming up, etc. « No Magic Pill http://www.bodyrecomposition.com/fat-loss/the-hormones-of-bodyweight-regulation-leptin-part-2.html/comment-page-1#comment-131 Warming up, etc. « No Magic Pill Sun, 17 Aug 2008 14:42:28 +0000 http://www.bodyrecomposition.com/blog/2008/08/15/the-hormones-of-bodyweight-regulation-leptin-part-2/#comment-131 [...] gets geeky (okay, that’s redundant) talking about the role of leptin in obesity (one and two). I should mention that, based on his suggestion in an earlier post, Why Zebras Don’t Get [...] [...] gets geeky (okay, that’s redundant) talking about the role of leptin in obesity (one and two). I should mention that, based on his suggestion in an earlier post, Why Zebras Don’t Get [...]

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