Effects of (-)-hydroxycitrate on Net Fat Synthesis as De Novo Lipogenesis
DNL has been the subject of much debate for years and many readers have probably seen it claimed that ‘carbs in excess of needs simply get converted to fat and stored’. This is true if you’re looking at rats, mice and hamsters. One study (Acheson et. al., 1982) in humans gave the subjects 500 grams of carbohydrates (2000 calories) all at once; conversion of carbs to fat was insignificant. The majority of research in humans has not found DNL to contribute significantly to fat gain except under a few very extreme conditions.
